Enforced C-Src Activation Causes Compartmental Dysregulation of PI3K and PTEN Molecules in Lipid Rafts of Tongue Squamous Carcinoma Cells by Attenuating Rac1-Akt-GLUT-1-Mediated Sphingolipid Synthesis

Enforced C-Src Activation Causes Compartmental Dysregulation of PI3K and PTEN Molecules in Lipid Rafts of Tongue Squamous Carcinoma Cells by Attenuating Rac1-Akt-GLUT-1-Mediated Sphingolipid Synthesis

Pharmacologic intervention to affect the membrane lipid homeostasis of lipid rafts is a potent therapeutic strategy for cancer. Here we showed that gallic acid (GA) caused the complex formation of inactive Ras-related C3 botulinum toxin substrate 1 (Rac1)-phospho (p)-casein kinase 2 α (CK2α) (Tyr 25...

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Bibliographic Details
Main Authors: Chien-Wei Wu, Shyang-Guang Wang, Ching-Hsiao Lee, Wen-Ling Chan, Meng-Liang Lin, Shih-Shun Chen
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
c-Src
casein kinase 2
cell invasion
gallic acid
GLUT-1
lipid raft
Online Access:https://www.mdpi.com/1422-0067/21/16/5812

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https://www.mdpi.com/1422-0067/21/16/5812

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