Molecular Analysis of a Multistep Lung Cancer Model Induced by Chronic Inflammation Reveals Epigenetic Regulation of p16, Activation of the DNA Damage Response Pathway

Molecular Analysis of a Multistep Lung Cancer Model Induced by Chronic Inflammation Reveals Epigenetic Regulation of p16, Activation of the DNA Damage Response Pathway

The molecular hallmarks of inflammation-mediated lung carcinogenesis have not been fully clarified, mainly due to the scarcity of appropriate animal models. We have used a silica-induced multistep lung carcinogenesis model driven by chronic inflammation to study the evolution of molecular markers,...

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Bibliographic Details
Main Authors: David Blanco, Silvestre Vicent, Mario F. Fraga, Ignacio Fernandez-Garcia, Javier Freire, Amaia Lujambio, Manel Esteller, Carlos Ortiz-de-Solorzano, Ruben Pio, Fernando Lecanda, Luis M. Montuenga
Format: Article
Language:English
Published: Elsevier 2007-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
lung cancer
inflammation
animal model
preneoplastic lesions
DNA damage response
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800649

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http://www.sciencedirect.com/science/article/pii/S1476558607800649

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