Microglial Cell Morphology and Phagocytic Activity Are Critically Regulated by the Neurosteroid Allopregnanolone: A Possible Role in Neuroprotection

Microglial Cell Morphology and Phagocytic Activity Are Critically Regulated by the Neurosteroid Allopregnanolone: A Possible Role in Neuroprotection

Microglial cells are key players in neural pathogenesis and microglial function regulation appears to be pivotal in controlling neuroinflammatory/neurological diseases. Here, we investigated the effects and mechanism of action of neurosteroid allopregnanolone (ALLO) on murine microglial BV-2 cells a...

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Bibliographic Details
Main Authors: Valérie Jolivel, Susana Brun, Fabien Binamé, Jérémie Benyounes, Omar Taleb, Dominique Bagnard, Jérôme De Sèze, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
microglia
neurosteroid
allopregnanolone
GABA-A receptor
oligodendrocyte
multiple sclerosis
Online Access:https://www.mdpi.com/2073-4409/10/3/698

Internet

https://www.mdpi.com/2073-4409/10/3/698

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