Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol.

Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol.

Mammalian target of rapamycin (mTOR)/S6K1 signalling emerges as a critical regulator of aging. Yet, a role of mTOR/S6K1 in aging-associated vascular endothelial dysfunction remains unknown. In this study, we investigated the role of S6K1 in aging-associated endothelial dysfunction and effects of the...

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Bibliographic Details
Main Authors: Angana G Rajapakse, Gautham Yepuri, João M Carvas, Sokrates Stein, Christian M Matter, Isabelle Scerri, Jean Ruffieux, Jean-Pierre Montani, Xiu-Fen Ming, Zhihong Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3081344?pdf=render

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http://europepmc.org/articles/PMC3081344?pdf=render

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