A Negative Feedback Loop in Ultraviolet A-Induced Senescence in Human Dermal Fibroblasts Formed by SPCA1 and MAPK

A Negative Feedback Loop in Ultraviolet A-Induced Senescence in Human Dermal Fibroblasts Formed by SPCA1 and MAPK

Secretory pathway calcium ATPase 1 (SPCA1) is a calcium pump localized specifically to the Golgi. Its effects on UVA-induced senescence have never been examined. In our study, expression of SPCA1 was increased in UVA-irradiated human dermal fibroblasts (HDFs) by activating mitogen-activated protein...

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Bibliographic Details
Main Authors: Hongfu Xie, Xiao Xiao, Yuxin Yi, Mingxing Deng, Peihui Li, Dan Jian, Zhili Deng, Ji Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
SPCA1
UVA
intracellular calcium concentration
ROS
MAPK pathway
negative feedback
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.597993/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.597993/full

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