Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function.

We assessed whether the nuclear localization sequences (NLS) and C terminus of parathyroid hormone-related protein (PTHrP) play critical roles in brain development and function. We used histology, immunohistochemistry, histomorphometry, Western blots and electrophysiological recordings to compare th...

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Bibliographic Details
Main Authors: Zhen Gu, Yahong Liu, Yongjie Zhang, Shulei Jin, Qi Chen, David Goltzman, Andrew Karaplis, Dengshun Miao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3402381?pdf=render