Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

Apoptosis is characterized by profound morphological changes, but their physiological purpose is unknown. To characterize the role of apoptotic cell contraction, ROCK1 was rendered caspase non-cleavable (ROCK1nc) by mutating aspartate 1113, which revealed that ROCK1 cleavage was necessary for forcef...

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Bibliographic Details
Main Authors: Linda Julian, Gregory Naylor, Grant R Wickman, Nicola Rath, Giovanni Castino, David Stevenson, Sheila Bryson, June Munro, Lynn McGarry, Margaret Mullin, Alistair Rice, Armandodel Del Río Hernández, Michael F Olson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
apoptosis
cytoskeleton
signal transduction
protein kinase
Online Access:https://elifesciences.org/articles/61983

Internet

https://elifesciences.org/articles/61983

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