Docking Studies and α-Substitution Effects on the Anti-Inflammatory Activity of β-Hydroxy-β-arylpropanoic Acids

Docking Studies and α-Substitution Effects on the Anti-Inflammatory Activity of β-Hydroxy-β-arylpropanoic Acids

Six β-hydroxy-β-aryl propanoic acids were synthesised using a modification of Reformatsky reaction which has already been reported. These acids belong to the aryl propanoic acid class of compounds, structurally similar to the NSAIDs, such as ibuprofen, and an anti-inflammatory activity is thus expec...

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Bibliographic Details
Main Authors: Ivan O. Juranić, Sote M. Vladimirov, Marina T. Milenković, Bojan D. Marković, Jelena S. Savić, Sanda P. Dilber
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Molecules
Subjects:
β-hydroxy-β-arylpropanoic acids
Reformatsky reaction
anti-inflammatory activity
molecular docking simulations
COX-2 selective inhibitor
Online Access:http://www.mdpi.com/1420-3049/16/8/6645/

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http://www.mdpi.com/1420-3049/16/8/6645/

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