Estrogen Receptor (ER)-α36 Is Involved in Estrogen- and Tamoxifen-Induced Neuroprotective Effects in Ischemic Stroke Models.

Estrogen Receptor (ER)-α36 Is Involved in Estrogen- and Tamoxifen-Induced Neuroprotective Effects in Ischemic Stroke Models.

The neuroprotection by estrogen (E2) and tamoxifen is well documented in experimental stroke models; however, the exact mechanism is unclear. A membrane-based estrogen receptor, ER-α36, has been identified. Postmenopausal-levels of E2 act through ER-α36 to induce osteoclast apoptosis due to a prolon...

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Bibliographic Details
Main Authors: Wei Zou, Chen Fang, Xiaofei Ji, Xiaofeng Liang, Yang Liu, Chao Han, Liang Huang, Qiqi Zhang, Hongyan Li, Yejun Zhang, Jinqiu Liu, Jing Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4618921?pdf=render

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http://europepmc.org/articles/PMC4618921?pdf=render

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