Estrogen Receptor (ER)-α36 Is Involved in Estrogen- and Tamoxifen-Induced Neuroprotective Effects in Ischemic Stroke Models.
The neuroprotection by estrogen (E2) and tamoxifen is well documented in experimental stroke models; however, the exact mechanism is unclear. A membrane-based estrogen receptor, ER-α36, has been identified. Postmenopausal-levels of E2 act through ER-α36 to induce osteoclast apoptosis due to a prolon...
Main Authors: | Wei Zou, Chen Fang, Xiaofei Ji, Xiaofeng Liang, Yang Liu, Chao Han, Liang Huang, Qiqi Zhang, Hongyan Li, Yejun Zhang, Jinqiu Liu, Jing Liu |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4618921?pdf=render |
Similar Items
-
Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer
by: Melissa A. Maczis, et al.
Published: (2018-12-01) -
Tamoxifen metabolites can target both aromatase and estrogen receptors
by: Liu, Jinzhong
Published: (2016) -
Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury
by: Jiaxuan He, et al.
Published: (2018-07-01) -
ER-α36-mediated rapid estrogen signaling positively regulates ER-positive breast cancer stem/progenitor cells.
by: Hao Deng, et al.
Published: (2014-01-01) -
Identification and Analysis of Estrogen Receptor α Promoting Tamoxifen Resistance-Related lncRNAs
by: Xiulei Zhang, et al.
Published: (2020-01-01)