Protective efficacy of an attenuated Mtb ΔLprG vaccine in mice.

Protective efficacy of an attenuated Mtb ΔLprG vaccine in mice.

Bacille Calmette-Guerin (BCG), an attenuated whole cell vaccine based on Mycobacterium bovis, is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), but its efficacy is suboptimal and it fails to protect against pulmonary tuberculosis. We previously reported that Mtb lacking the viru...

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Bibliographic Details
Main Authors: Amanda J Martinot, Eryn Blass, Jingyou Yu, Malika Aid, Shant H Mahrokhian, Sara B Cohen, Courtney R Plumlee, Rafael A Larocca, Noman Siddiqi, Shoko Wakabayashi, Michelle Gardner, Rebecca Audette, Anne Devorak, Kevin B Urdahl, Eric J Rubin, Dan H Barouch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009096

Internet

https://doi.org/10.1371/journal.ppat.1009096

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