Nuclear reprogramming: kinetics of cell cycle and metabolic progression as determinants of success.

Nuclear reprogramming: kinetics of cell cycle and metabolic progression as determinants of success.

Establishment of totipotency after somatic cell nuclear transfer (NT) requires not only reprogramming of gene expression, but also conversion of the cell cycle from quiescence to the precisely timed sequence of embryonic cleavage. Inadequate adaptation of the somatic nucleus to the embryonic cell cy...

Full description

Bibliographic Details
Main Authors: Sebastian Thomas Balbach, Telma Cristina Esteves, Franchesca Dawn Houghton, Marcin Siatkowski, Martin Johannes Pfeiffer, Chizuko Tsurumi, Benoit Kanzler, Georg Fuellen, Michele Boiani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3329427?pdf=render

Internet

http://europepmc.org/articles/PMC3329427?pdf=render

Similar Items