Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

Abstract Background Proteolytic processing of the prion protein (PrPC) by endogenous proteases generates bioactive membrane-bound and soluble fragments which may help to explain the pleiotropic roles of this protein in the nervous system and in brain diseases. Shedding of almost full-length PrPC int...

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Bibliographic Details
Main Authors: Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel, Hermann C. Altmeppen
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Molecular Neurodegeneration
Subjects:
ADAM10
Antibody
Exosomes
Glycosylation
Membrane anchor
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s13024-018-0248-6

Internet

http://link.springer.com/article/10.1186/s13024-018-0248-6

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