Successful pregnancy after prenatal diagnosis by NGS for a carrier of complex chromosome rearrangements

Successful pregnancy after prenatal diagnosis by NGS for a carrier of complex chromosome rearrangements

Abstract Background The study is aimed to provide prediction for fertility risk in the setting of assisted reproduction for a woman with complex chromosomal rearrangements (CCRs). Methods We implemented a robust approach, which combined whole-genome low-coverage mate-pair sequencing (WGL-MPS), junct...

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Bibliographic Details
Main Authors: Jian Ou, Chuanchun Yang, Xiaoli Cui, Chuan Chen, Suyan Ye, Cai Zhang, Kai Wang, Jianguo Chen, Qin Zhang, Chunfeng Qian, Guangguang Fang, Wenyong Zhang
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Reproductive Biology and Endocrinology
Subjects:
Complex chromosomal rearrangements
Breakpoints mapping
Whole-genome low-coverage mate-pair sequencing
Preimplantation genetic testing for aneuploidy
Junction-spanning PCR
Online Access:http://link.springer.com/article/10.1186/s12958-020-00572-5

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http://link.springer.com/article/10.1186/s12958-020-00572-5

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