Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB

NifB is a key enzyme in the biosynthesis pathway of the nitrogenase FeMo cofactor. Here, the authors investigate the maturation of its iron-sulfur clusters by EPR and biochemical analyses, showing how individual precursor clusters participate in the formation of the final iron-sulfur cluster.

Bibliographic Details
Main Authors:	Lee A. Rettberg, Jarett Wilcoxen, Chi Chung Lee, Martin T. Stiebritz, Kazuki Tanifuji, R. David Britt, Yilin Hu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05272-8

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spelling	doaj-56364fc93c10486c9bfa448f202ababd2021-05-11T09:52:13ZengNature Publishing GroupNature Communications2041-17232018-07-01911810.1038/s41467-018-05272-8Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifBLee A. Rettberg0Jarett Wilcoxen1Chi Chung Lee2Martin T. Stiebritz3Kazuki Tanifuji4R. David Britt5Yilin Hu6Department of Molecular Biology and Biochemistry, University of CaliforniaDepartment of Chemistry, University of CaliforniaDepartment of Molecular Biology and Biochemistry, University of CaliforniaDepartment of Molecular Biology and Biochemistry, University of CaliforniaDepartment of Molecular Biology and Biochemistry, University of CaliforniaDepartment of Chemistry, University of CaliforniaDepartment of Molecular Biology and Biochemistry, University of CaliforniaNifB is a key enzyme in the biosynthesis pathway of the nitrogenase FeMo cofactor. Here, the authors investigate the maturation of its iron-sulfur clusters by EPR and biochemical analyses, showing how individual precursor clusters participate in the formation of the final iron-sulfur cluster.https://doi.org/10.1038/s41467-018-05272-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lee A. Rettberg Jarett Wilcoxen Chi Chung Lee Martin T. Stiebritz Kazuki Tanifuji R. David Britt Yilin Hu
spellingShingle	Lee A. Rettberg Jarett Wilcoxen Chi Chung Lee Martin T. Stiebritz Kazuki Tanifuji R. David Britt Yilin Hu Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB Nature Communications
author_facet	Lee A. Rettberg Jarett Wilcoxen Chi Chung Lee Martin T. Stiebritz Kazuki Tanifuji R. David Britt Yilin Hu
author_sort	Lee A. Rettberg
title	Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB
title_short	Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB
title_full	Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB
title_fullStr	Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB
title_full_unstemmed	Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB
title_sort	probing the coordination and function of fe4s4 modules in nitrogenase assembly protein nifb
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	NifB is a key enzyme in the biosynthesis pathway of the nitrogenase FeMo cofactor. Here, the authors investigate the maturation of its iron-sulfur clusters by EPR and biochemical analyses, showing how individual precursor clusters participate in the formation of the final iron-sulfur cluster.
url	https://doi.org/10.1038/s41467-018-05272-8
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Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB

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