Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line

Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line

Onion (Allium cepa) is being studied as a potential anticancer agent, but little is known regarding its effect in multidrug resistance (MDR) cells. In this work, the cytotoxicity of crude onion extract (OE) and fractioned extract (aqueous, methanolic and ethyl acetate), as well as some onion compoun...

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Bibliographic Details
Main Authors: Ana P. S Votto, Beatriz S Domingues, Michele M de Souza, Flavio M. R da Silva Júnior, Sergiane S Caldas, Daza M. V. B Filgueira, Rosilene M Clementin, Ednei G Primel, Adriana L Vallochi, Eliana B Furlong, Gilma S Trindade
Format: Article
Language:English
Published: BMC 2010-01-01
Series:Biological Research
Subjects:
antioxidant
apoptosis and/or necrosis
DNA damage
MDR phenotype
onion (Allium cepa)
tumoral cell
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400007

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400007

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