Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and Human Monocyte Cell Line

Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and Human Monocyte Cell Line

Toxoplasma gondii is able to infect a wide range of vertebrates, including humans. Studies show that cyclooxygenase-2 (COX-2) is a modulator of immune response in multiple types of infection, such as Trypanosoma cruzi. However, the role of COX-2 during T. gondii infection is still unclear. The aim o...

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Bibliographic Details
Main Authors: Ana Carolina Alcântara Pereira, Rafaela José Silva, Priscila Silva Franco, Angelica de Oliveira Gomes, Guilherme Souza, Iliana Claudia Balga Milian, Mayara Ribeiro, Alessandra Monteiro Rosini, Pâmela Mendonça Guirelli, Eliézer Lucas Pires Ramos, Tiago Wilson Patriarca Mineo, José Roberto Mineo, Neide Maria Silva, Eloisa Amália Vieira Ferro, Bellisa Freitas Barbosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
Toxoplasma gondii
cyclooxygenase-2
Calomys callosus
THP-1 cells
prostaglandin E2
immune response
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00225/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00225/full

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