The Hepatic Microenvironment and TRAIL-R2 Impact Outgrowth of Liver Metastases in Pancreatic Cancer after Surgical Resection

The Hepatic Microenvironment and TRAIL-R2 Impact Outgrowth of Liver Metastases in Pancreatic Cancer after Surgical Resection

Most patients with pancreatic ductal adenocarcinoma (PDAC) undergoing curative resection relapse within months, often with liver metastases. The hepatic microenvironment determines induction and reversal of dormancy during metastasis. Both tumor growth and metastasis depend on the Tumor necrosis fac...

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Bibliographic Details
Main Authors: Lauritz Miarka, Charlotte Hauser, Ole Helm, Dörthe Holdhof, Silje Beckinger, Jan-Hendrik Egberts, Jan-Paul Gundlach, Lennart Lenk, Sascha Rahn, Wolfgang Mikulits, Anna Trauzold, Susanne Sebens
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
liver microenvironment
liver metastasis
inflammation
surgery
TRAIL-R2
Online Access:https://www.mdpi.com/2072-6694/11/6/745

Internet

https://www.mdpi.com/2072-6694/11/6/745

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