Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

During wound induced hair follicle neogenesis (WIHN), stem cells regenerate hair follicles but how this arises is unclear. Here, the authors show that self-noncoding dsRNA activates the antiviral receptor TLR3 to induce intrinsic retinoic acid, which stimulates WIHN in mice, and in isolated human ke...

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Bibliographic Details
Main Authors: Dongwon Kim, Ruosi Chen, Mary Sheu, Noori Kim, Sooah Kim, Nasif Islam, Eric M. Wier, Gaofeng Wang, Ang Li, Angela Park, Wooyang Son, Benjamin Evans, Victoria Yu, Vicky P. Prizmic, Eugene Oh, Zixiao Wang, Jianshi Yu, Weiliang Huang, Nathan K. Archer, Zhiqi Hu, Nashay Clemetson, Amanda M. Nelson, Anna Chien, Ginette A. Okoye, Lloyd S. Miller, Gabriel Ghiaur, Sewon Kang, Jace W. Jones, Maureen A. Kane, Luis A. Garza
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10811-y

Internet

https://doi.org/10.1038/s41467-019-10811-y

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