Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome

Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome

Autism spectrum disorders affect millions of individuals worldwide, but their heterogeneity complicates therapeutic intervention that is essentially symptomatic. A versatile yet relevant model to rationally screen among hundreds of therapeutic options would help improving clinical practice. Here we...

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Bibliographic Details
Main Authors: Hélène Darville, Aurélie Poulet, Frédérique Rodet-Amsellem, Laure Chatrousse, Julie Pernelle, Claire Boissart, Delphine Héron, Caroline Nava, Anselme Perrier, Margot Jarrige, Francis Cogé, Mark J. Millan, Thomas Bourgeron, Marc Peschanski, Richard Delorme, Alexandra Benchoua
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:EBioMedicine
Subjects:
Autism
SHANK3
High throughput screening
Valproate
Lithium
Drug repurposing
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416302286

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http://www.sciencedirect.com/science/article/pii/S2352396416302286

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