Exposure of Human CD8+ T Cells to Type-2 Cytokines Impairs Division and Differentiation and Induces Limited Polarization

Exposure of Human CD8+ T Cells to Type-2 Cytokines Impairs Division and Differentiation and Induces Limited Polarization

Effector CD8+ T cells generally produce type-1 cytokines and mediators of the perforin/granzyme cytolytic pathway, yet type-2-polarized CD8+ cells (Tc2) are detected in type-2 (T2) cytokine-driven diseases such as asthma. It is unclear whether T2 cytokine exposure during activation is sufficient to...

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Bibliographic Details
Main Authors: Annette Fox, Kim L. Harland, Katherine Kedzierska, Anne Kelso
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cell
human
cytokine
IFN-γ
IL-4
differentiation and reprogramming
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01141/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01141/full

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