Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs.

Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs.

Parasitic nematodes are responsible for devastating illnesses that plague many of the world's poorest populations indigenous to the tropical areas of developing nations. Among these diseases is lymphatic filariasis, a major cause of permanent and long-term disability. Proteins essential to nema...

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Bibliographic Details
Main Authors: Jeremiah D Farelli, Brendan D Galvin, Zhiru Li, Chunliang Liu, Miyuki Aono, Megan Garland, Olivia E Hallett, Thomas B Causey, Alana Ali-Reynolds, Daniel J Saltzberg, Clotilde K S Carlow, Debra Dunaway-Mariano, Karen N Allen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4081830?pdf=render

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http://europepmc.org/articles/PMC4081830?pdf=render

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