Determination of moisture content in lyophilized mannitol through intact glass vials using NIR micro-spectrometers

Determination of moisture content in lyophilized mannitol through intact glass vials using NIR micro-spectrometers

Determination of moisture content in lyophilized solids is fundamental to predict quality and stability of freeze-dried products, but conventional methods are time-consuming, invasive and destructive. The aim of this study was to develop and optimize a fast, inexpensive, noninvasive and nondestructi...

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Bibliographic Details
Main Authors: Cristian Rodrigo Muzzio, Nicolás Gabriel Dini, Laura Daniela Simionato
Format: Article
Language:English
Published: Universidade de São Paulo 2011-06-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Espectroscopia de infravermelho próximo
Liofilização
Análise multivariada
Análise de unidade
Manitol
Microespectrômetro
Near-infrared spectroscopy
Lyophilization
Multivariate analysis
Moisture content
Mannitol
Micro-spectrometer
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200010

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200010

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