Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits

The dopamine transporter is a key protein responsible for regulating dopamine homeostasis. Its function is to transport dopamine from the extracellular space into the presynaptic neuron. Studies have suggested that accumulation of dopamine in the cytosol can trigger oxidative stress and neurotoxicit...

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Bibliographic Details
Main Authors: S.T. Masoud, L.M. Vecchio, Y. Bergeron, M.M. Hossain, L.T. Nguyen, M.K. Bermejo, B. Kile, T.D. Sotnikova, W.B. Siesser, R.R. Gainetdinov, R.M. Wightman, M.G. Caron, J.R. Richardson, G.W. Miller, A.J. Ramsey, M. Cyr, A. Salahpour
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Dopamine transporter
Parkinson's disease
Transgenic mice
Cytosolic dopamine
Dopamine neuron loss
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003295

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http://www.sciencedirect.com/science/article/pii/S0969996114003295

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