CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes.

CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes.

Most AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) arises from errors in immunoglobulin heavy-chain gene (IgH) class switch recombination (CSR) or somatic hypermutation (SHM), events that occur in germinal center (GC) B cells and require the activity of activation induced cytidine deaminase...

Full description

Bibliographic Details
Main Authors: Marta Epeldegui, Dharma R Thapa, Justin De la Cruz, Scott Kitchen, Jerome A Zack, Otoniel Martínez-Maza
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2897846?pdf=render

Internet

http://europepmc.org/articles/PMC2897846?pdf=render

Similar Items