Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling

Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling

Abstract Background The mechanistic (or mammalian) target of rapamycin (mTOR), a Ser/Thr kinase, associates with different subunits forming two functionally distinct complexes, mTORC1 and mTORC2, regulating a diverse set of cellular functions in response to growth factors, cellular energy levels, an...

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Bibliographic Details
Main Authors: Mehraj-U-Din Lone, Javed Miyan, Mohammad Asif, Showkat A. Malik, Parul Dubey, Varsha Singh, Kavita Singh, Kalyan Mitra, Deepali Pandey, Wahajul Haq, Himanshi Amita, Prince Kumar Singh, Wieland Kiess, Franziska Kaessner, Antje Garten, Smrati Bhadauria
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Cancer
Subjects:
Cancer
Mammalian target of rapamycin (mTOR)
Signaling
Ras
Superoxide anion
Online Access:https://doi.org/10.1186/s12885-019-6422-6

Internet

https://doi.org/10.1186/s12885-019-6422-6

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