The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence

AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete regions of the...

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Bibliographic Details
Main Authors: Romina Burla, Mariateresa Carcuro, Mattia La Torre, Federica Fratini, Marco Crescenzi, Maria Rosaria D'Apice, Paola Spitalieri, Grazia Daniela Raffa, Letizia Astrologo, Giovanna Lattanzi, Enrico Cundari, Domenico Raimondo, Annamaria Biroccio, Maurizio Gatti, Isabella Saggio
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Open Biology
Subjects:
lamin
telomeres
laminopathies
progeria
nuclear lamina
cell senescence
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160103

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160103

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