Gender-Specific Efficacy Revealed by Head-to-Head Comparison of Pasireotide and Octreotide in a Representative In Vivo Model of Nonfunctioning Pituitary Tumors

Gender-Specific Efficacy Revealed by Head-to-Head Comparison of Pasireotide and Octreotide in a Representative In Vivo Model of Nonfunctioning Pituitary Tumors

Invasive nonfunctioning pituitary tumors (NFPTs) are non-resectable neoplasms associated with frequent relapse and significant comorbidities. Current treatments, including somatostatin receptor 2 (SSTR2)-directed somatostatin analogs (SSAs), often fail against NFPTs. Thus, identifying effective ther...

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Bibliographic Details
Main Authors: Sebastian Gulde, Tobias Wiedemann, Mathias Schillmaier, Isabel Valença, Amelie Lupp, Katja Steiger, Hsi-Yu Yen, Stephen Bäuerle, Johannes Notni, Raul Luque, Herbert Schmid, Stefan Schulz, Donna P. Ankerst, Franz Schilling, Natalia S. Pellegata
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
nonfunctioning pituitary tumors
octreotide
pasireotide
somatostatin receptors
MRI
sex differences in drug response
Online Access:https://www.mdpi.com/2072-6694/13/12/3097

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https://www.mdpi.com/2072-6694/13/12/3097

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