Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation

Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation

Abstract Background Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models. Search for identification of toxic factor(s) in CSF revealed an enhancement in the level and enzyme activity of chitotr...

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Main Authors: Anu Mary Varghese, Mausam Ghosh, Savita Kumari Bhagat, K. Vijayalakshmi, Veeramani Preethish-Kumar, Seena Vengalil, Pradeep-Chandra-Reddy Chevula, Saraswati Nashi, Kiran Polavarapu, Meenakshi Sharma, Rupinder Singh Dhaliwal, Mariamma Philip, Atchayaram Nalini, Phalguni Anand Alladi, Talakad N. Sathyaprabha, Trichur R. Raju
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
Chitotriosidase
Amyotrophic lateral sclerosis
Biomarker
Neuroinflammation
Glia
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s12974-020-01909-y

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http://link.springer.com/article/10.1186/s12974-020-01909-y

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