Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections

Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections

Although enterovirus D68 poses a major global threat to children, neither vaccines nor therapeutics are currently available. Using Cryo-EM, Zhang et al. show that two murine-derived monoclonal antibodies with therapeutic efficacy neutralize virions via binding to the canyon region, creating steric h...

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Bibliographic Details
Main Authors: Chao Zhang, Cong Xu, Wenlong Dai, Yifan Wang, Zhi Liu, Xueyang Zhang, Xuesong Wang, Haikun Wang, Sitang Gong, Yao Cong, Zhong Huang
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23199-5

Internet

https://doi.org/10.1038/s41467-021-23199-5

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