Radiobiological and dosimetric assessment of DNA-intercalated 99mTc-complexes bearing acridine orange derivatives

Abstract Background Recently, a new family of 99mTc(I)-tricarbonyl complexes bearing an acridine orange (AO) DNA targeting unit and different linkers between the Auger emitter (99mTc) and the AO moiety was evaluated for Auger therapy. Among them, 99mTc-C3 places the corresponding radionuclide at a s...

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Bibliographic Details
Main Authors: Ana Belchior, Salvatore Di Maria, Célia Fernandes, Pedro Vaz, António Paulo, Paula Raposinho
Format: Article
Language:English
Published: SpringerOpen 2020-07-01
Series:EJNMMI Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13550-020-00663-9