In-Depth Analysis of the Impact of Different Serum-Free Media on the Production of Clinical Grade Dendritic Cells for Cancer Immunotherapy

In-Depth Analysis of the Impact of Different Serum-Free Media on the Production of Clinical Grade Dendritic Cells for Cancer Immunotherapy

Dendritic cell (DC)-based antitumor vaccines have proven to be a safe approach, but often fail to generate robust results between trials. Translation to the clinic has been hindered in part by the lack of standard operation procedures for vaccines production, namely the definition of optimal culture...

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Bibliographic Details
Main Authors: João Calmeiro, Luís Mendes, Iola F. Duarte, Catarina Leitão, Adriana R. Tavares, Daniel Alexandre Ferreira, Célia Gomes, João Serra, Amílcar Falcão, Maria Teresa Cruz, Mylène A. Carrascal, Bruno Miguel Neves
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
dendritic cells vaccines
clinical grade serum-free media
metabolic activity
dendritic cell differentiation
CTL priming
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.593363/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.593363/full

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