Development of a LC-ESI-MRM method for the absolute quantification of orexin A in the CSF of individual mice

Development of a LC-ESI-MRM method for the absolute quantification of orexin A in the CSF of individual mice

Sleep-wakefulness is disrupted in most neurological and psychiatric disorders. Although clinical data implicate orexin (hypocretin), a crucial sleep/wake regulatory neuropeptide, in such disorders, limited sample volumes effectively prevent quantification of cerebrospinal fluid (CSF) levels of orexi...

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Bibliographic Details
Main Authors: Katherine Hopkins, Soumya Mukherjee, Dalia Ponce, Jonathan Mangum, Laura H. Jacobson, Daniel Hoyer
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Medicine in Drug Discovery
Subjects:
Animal models
Arousal
Mass spectrometry
Mice
Orexins/hypocretins
Sleep
Online Access:http://www.sciencedirect.com/science/article/pii/S2590098621000233

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http://www.sciencedirect.com/science/article/pii/S2590098621000233

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