c-Myc Upregulated by High Glucose Inhibits HaCaT Differentiation by S100A6 Transcriptional Activation

c-Myc Upregulated by High Glucose Inhibits HaCaT Differentiation by S100A6 Transcriptional Activation

Keratinocyte differentiation dysfunction in diabetic skin is closely related to impaired skin barrier functions. We investigated the effects of c-Myc and S100A6 on Human immortal keratinocyte line (HaCaT) or keratinocyte differentiation and potential mechanisms. The expression levels of differentiat...

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Bibliographic Details
Main Authors: Jie Zhang, Peilang Yang, Dan Liu, Min Gao, Jizhuang Wang, Xiqiao Wang, Yan Liu, Xiong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Endocrinology
Subjects:
c-Myc
S100A6
differentiation
diabetes
wound healing
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.676403/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.676403/full

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