Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation

Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation

Abstract Background Endothelial-dependent atherosclerosis develops in a non-random pattern in regions of vessel bending and bifurcations, where blood flow exhibits disturbed flow (DF) patterns. In contrast, uniform flow (UF), normal endothelium, and healthy vessel walls co-exist within straight vess...

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Bibliographic Details
Main Authors: Ian C. Harding, Ronodeep Mitra, Solomon A. Mensah, Ira M. Herman, Eno E. Ebong
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Translational Medicine
Subjects:
Atherosclerosis
Endothelial cells
Fluid shear stress
Glycocalyx
Caveolin
Endothelial-type nitric oxide synthase
Online Access:http://link.springer.com/article/10.1186/s12967-018-1721-2

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http://link.springer.com/article/10.1186/s12967-018-1721-2

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