Inhibition of iNKT Cells by the HLA-G-ILT2 Checkpoint and Poor Stimulation by HLA-G-Expressing Tolerogenic DC

Inhibition of iNKT Cells by the HLA-G-ILT2 Checkpoint and Poor Stimulation by HLA-G-Expressing Tolerogenic DC

Invariant Natural Killer T (iNKT) cells are a small and distinct population of T cells crucial in immunomodulation. After activation by alpha-GalactosylCeramide (αGC), an exogenic glycolipid antigen, iNKT cells can rapidly release cytokines to enhance specific anti-tumor activity. Several human clin...

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Bibliographic Details
Main Authors: Ching-Lien Wu, Julien Caumartin, Giada Amodio, François Anna, Maria Loustau, Silvia Gregori, Pierre Langlade-Demoyen, Joel LeMaoult
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
Human Leucocyte Antigen G
Natural Killer T cells
immune regulation
tolerogenic dendritic cells
ILT2/CD85j/LILRB1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.608614/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.608614/full

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