Interferon lambda protects the female reproductive tract against Zika virus infection

Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood. Here, the authors examine the immune basis of vaginal protection and susceptibility to Zika viral infection, and identify a hormonal dependent rol...

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Main Authors:	Elizabeth A. Caine, Suzanne M. Scheaffer, Nitin Arora, Konstantin Zaitsev, Maxim N. Artyomov, Carolyn B. Coyne, Kelle H. Moley, Michael S. Diamond
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-07993-2

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spelling	doaj-568be70d5e744aafb4350b13e5aaa00d2021-05-11T12:09:27ZengNature Publishing GroupNature Communications2041-17232019-01-0110111210.1038/s41467-018-07993-2Interferon lambda protects the female reproductive tract against Zika virus infectionElizabeth A. Caine0Suzanne M. Scheaffer1Nitin Arora2Konstantin Zaitsev3Maxim N. Artyomov4Carolyn B. Coyne5Kelle H. Moley6Michael S. Diamond7Departments of Medicine, Washington University School of MedicineObstetrics and Gynecology, Washington University School of MedicineDepartments of Pediatrics, University of Pittsburgh School of MedicineDepartment of Pathology and Immunology, Washington University School of MedicineDepartment of Pathology and Immunology, Washington University School of MedicineDepartments of Pediatrics, University of Pittsburgh School of MedicineObstetrics and Gynecology, Washington University School of MedicineDepartments of Medicine, Washington University School of MedicineZika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood. Here, the authors examine the immune basis of vaginal protection and susceptibility to Zika viral infection, and identify a hormonal dependent role for interferon-lambda-mediated protection against disease.https://doi.org/10.1038/s41467-018-07993-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Elizabeth A. Caine Suzanne M. Scheaffer Nitin Arora Konstantin Zaitsev Maxim N. Artyomov Carolyn B. Coyne Kelle H. Moley Michael S. Diamond
spellingShingle	Elizabeth A. Caine Suzanne M. Scheaffer Nitin Arora Konstantin Zaitsev Maxim N. Artyomov Carolyn B. Coyne Kelle H. Moley Michael S. Diamond Interferon lambda protects the female reproductive tract against Zika virus infection Nature Communications
author_facet	Elizabeth A. Caine Suzanne M. Scheaffer Nitin Arora Konstantin Zaitsev Maxim N. Artyomov Carolyn B. Coyne Kelle H. Moley Michael S. Diamond
author_sort	Elizabeth A. Caine
title	Interferon lambda protects the female reproductive tract against Zika virus infection
title_short	Interferon lambda protects the female reproductive tract against Zika virus infection
title_full	Interferon lambda protects the female reproductive tract against Zika virus infection
title_fullStr	Interferon lambda protects the female reproductive tract against Zika virus infection
title_full_unstemmed	Interferon lambda protects the female reproductive tract against Zika virus infection
title_sort	interferon lambda protects the female reproductive tract against zika virus infection
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-01-01
description	Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood. Here, the authors examine the immune basis of vaginal protection and susceptibility to Zika viral infection, and identify a hormonal dependent role for interferon-lambda-mediated protection against disease.
url	https://doi.org/10.1038/s41467-018-07993-2
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Interferon lambda protects the female reproductive tract against Zika virus infection

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