Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice

Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice

Variants of the SH3 and multiple ankyrin repeat domain 3 (SHANK3) gene, encoding excitatory postsynaptic core scaffolding proteins, are causally associated with numerous neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorder (ASD), bipolar disorder, intellectual disabi...

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Bibliographic Details
Main Authors: Chunmei Jin, Hyojin Kang, Jae Ryun Ryu, Shinhyun Kim, Yinhua Zhang, Yeunkum Lee, Yoonhee Kim, Kihoon Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Shank3
mPFC
striatum
transcriptome
myelin
GPR85
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00250/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00250/full

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