ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis.

ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis.

Airways infection with Mycobacterium tuberculosis (Mtb) is contained mostly by T cell responses, however, Mtb has developed evasion mechanisms which affect antigen presenting cell (APC) maturation/recruitment delaying the onset of Ag-specific T cell responses. Hypothetically, bypassing the natural i...

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Bibliographic Details
Main Authors: Aarón Silva-Sánchez, Selene Meza-Pérez, Adriana Flores-Langarica, Luis Donis-Maturano, Iris Estrada-García, Juana Calderón-Amador, Rogelio Hernández-Pando, Juliana Idoyaga, Ralph M Steinman, Leopoldo Flores-Romo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0124828

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https://doi.org/10.1371/journal.pone.0124828

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