Evasion of Immune Surveillance in Low Oxygen Environments Enhances Candida albicans Virulence

Evasion of Immune Surveillance in Low Oxygen Environments Enhances Candida albicans Virulence

Successful human colonizers have evolved mechanisms to bypass immune surveillance. Infiltration of PMNs to the site of infection led to the generation of a low oxygen niche. Exposure to low oxygen levels induced fungal cell wall masking, which in turn hindered pathogen sensing and antifungal respons...

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Bibliographic Details
Main Authors: José Pedro Lopes, Marios Stylianou, Emelie Backman, Sandra Holmberg, Jana Jass, Rolf Claesson, Constantin F. Urban
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mBio
Subjects:
Candida albicans
neutrophil
PMN
anoxia
hypoxia
immune evasion
fungal masking
fungal cell wall
abscesses
beta-glucan
mycology
Online Access:https://doi.org/10.1128/mBio.02120-18

Internet

https://doi.org/10.1128/mBio.02120-18

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