Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism

Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism

Multiple signaling pathways in the adult Drosophila enterocyte sense cellular damage or stress and signal to intestinal stem cells (ISCs) to undergo proliferation and differentiation, thereby maintaining intestinal homeostasis. Here we show that misregulation of mitochondrial pyruvate metabolism in...

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Bibliographic Details
Main Authors: Dona R. Wisidagama, Carl S. Thummel
Format: Article
Language:English
Published: Oxford University Press 2019-11-01
Series:G3: Genes, Genomes, Genetics
Subjects:
mitochondria
intestinal homeostasis
metabolism
stem cells
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400633

Internet

http://g3journal.org/lookup/doi/10.1534/g3.119.400633

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