Precursor B-ALL Cell Lines Differentially Respond to SYK Inhibition by Entospletinib

Precursor B-ALL Cell Lines Differentially Respond to SYK Inhibition by Entospletinib

Background: Impaired B-cell receptor (BCR) function has been associated with the progress of several B-cell malignancies. The spleen tyrosine kinase (SYK) represents a potential therapeutic target in a subset of B-cell neoplasias. In precursor B-acute lymphoblastic leukemia (B-ALL), the pathogenic r...

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Bibliographic Details
Main Authors: Sina Sender, Anett Sekora, Simon Villa Perez, Oleksandra Chabanovska, Annegret Becker, Anaclet Ngezahayo, Christian Junghanss, Hugo Murua Escobar
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
entospletinib
Ento
GS-9973
B-ALL
acute lymphoblastic leukemia
expression analysis
Online Access:https://www.mdpi.com/1422-0067/22/2/592

Internet

https://www.mdpi.com/1422-0067/22/2/592

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