Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells

Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells

In mammals, the carboxy-terminal domain (CTD) of RNA polymerase (Pol) II consists of 52 conserved heptapeptide repeats containing the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Post-translational modifications of the CTD coordinate the transcription cycle and various steps of mRNA matura...

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Bibliographic Details
Main Authors: Nicolas Descostes, Martin Heidemann, Lionel Spinelli, Roland Schüller, Muhammad Ahmad Maqbool, Romain Fenouil, Frederic Koch, Charlène Innocenti, Marta Gut, Ivo Gut, Dirk Eick, Jean-Christophe Andrau
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
RNA polymerase II
carboxyl terminal domain
antisense transcription
enhancer
initiation
transcription
Online Access:https://elifesciences.org/articles/02105

Internet

https://elifesciences.org/articles/02105

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