Endo-Selective Construction of Spiro-[butyrolactone-pyrrolidine] via Ag(I)/CAAA-Amidphos-Catalyzed 1,3-Dipolar Cycloaddition between Azomethine Ylides and α-Methylene-γ-Butyrolactone

Endo-Selective Construction of Spiro-[butyrolactone-pyrrolidine] via Ag(I)/CAAA-Amidphos-Catalyzed 1,3-Dipolar Cycloaddition between Azomethine Ylides and α-Methylene-γ-Butyrolactone

Construction of spirocyclic pyrrolidines bearing a spiro quaternary stereocenter is an enormous challenge in synthetic organic chemistry. In this report, we introduce a Ag(I)/CAAA-amidphos-catalyzed enantioselective 1,3-dipolar cycloaddition between azomethine ylides and α-methylene-&#9...

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Bibliographic Details
Main Authors: Qinglin Hou, Yaoyao You, Xinluo Song, Yingxia Wang, Ke Chen, Haifei Wang
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Catalysts
Subjects:
<i>endo</i>-selective
1,3-dipolar cycloaddition
caaa-amidphos
azomethine ylides
spirocyclic pyrrolidines
Online Access:https://www.mdpi.com/2073-4344/10/1/28

Internet

https://www.mdpi.com/2073-4344/10/1/28

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