fMRI Reveals Mitigation of Cerebrovascular Dysfunction by Bradykinin Receptors 1 and 2 Inhibitor Noscapine in a Mouse Model of Cerebral Amyloidosis

fMRI Reveals Mitigation of Cerebrovascular Dysfunction by Bradykinin Receptors 1 and 2 Inhibitor Noscapine in a Mouse Model of Cerebral Amyloidosis

Functional magnetic resonance imaging (fMRI) techniques can be used to assess cerebrovascular dysfunction in Alzheimer’s disease, an important and early contributor to pathology. We hypothesized that bradykinin receptor inhibition alleviates the vascular dysfunction in a transgenic arcAβ mouse model...

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Bibliographic Details
Main Authors: Ruiqing Ni, Diana Rita Kindler, Rebecca Waag, Marie Rouault, Priyanka Ravikumar, Roger Nitsch, Markus Rudin, Giovanni G. Camici, Luca Liberale, Luka Kulic, Jan Klohs
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
beta-amyloid
bradykinin receptor
cerebral blood volume
cerebrovascular dysfunction
magnetic resonance imaging
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00027/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00027/full

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