Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos

Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos

High mitochondrial DNA (mtDNA) copy numbers are essential for oogenesis and embryogenesis and correlate with fertility of oocytes and viability of embryos. To understand the pathology and mechanisms associated with low mtDNA copy numbers, we knocked down mitochondrial transcription factor A (tfam),...

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Bibliographic Details
Main Authors: Auke B. C. Otten, Rick Kamps, Patrick Lindsey, Mike Gerards, Hélène Pendeville-Samain, Marc Muller, Florence H. J. van Tienen, Hubert J. M. Smeets
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mtDNA bottleneck
zebrafish embryogenesis
OXPHOS deficiency
transcriptomics
TFAM
mitochondria
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00381/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00381/full

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