Endogenous Apelin Is Protective Against Age-Associated Loss of Retinal Ganglion Cells in Mice

Endogenous Apelin Is Protective Against Age-Associated Loss of Retinal Ganglion Cells in Mice

Age-associated loss of retinal ganglion cells (RGCs) causes visual deficits, but there is not yet any therapeutic agent to prevent the loss of these cells. Herein, we report that apelin, an endogenous peptide ligand of APJ receptor, is protective against the age-related loss of RGCs in mice. The mRN...

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Bibliographic Details
Main Authors: Yuki Ishimaru, Akihide Sumino, Fumiya Shibagaki, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
retinal ganglion cell (RGC)
apelin
aging
knock-out
cell loss
apelin receptor (APJ)
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00058/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.00058/full

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