Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes
Abstract In recent years, phenotypic-based screens have become increasingly popular in drug discovery. A major challenge of this approach is that it does not provide information about the mechanism of action of the hits. This has led to the development of multiple strategies for target deconvolution...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-06-01
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| Series: | Proteome Science |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12953-017-0122-4 |