Claudin-7 Modulates Cl<sup>−</sup> and Na<sup>+</sup> Homeostasis and WNK4 Expression in Renal Collecting Duct Cells

Claudin-7 Modulates Cl<sup>−</sup> and Na<sup>+</sup> Homeostasis and WNK4 Expression in Renal Collecting Duct Cells

Claudin-7 knockout (CLDN7<sup>&#8722;/&#8722;</sup>) mice display renal salt wasting and dehydration phenotypes. To address the role of CLDN7 in kidneys, we established collecting duct (CD) cell lines from CLDN7<sup>+/+</sup> and CLDN7<sup>&#8722;/&#8722...

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Bibliographic Details
Main Authors: Junming Fan, Rodney Tatum, John Hoggard, Yan-Hua Chen
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
Claudin-7
tight junctions
permeability
WNK4
epithelial sodium channel (ENaC), collecting duct cells
Online Access:https://www.mdpi.com/1422-0067/20/15/3798

Internet

https://www.mdpi.com/1422-0067/20/15/3798

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