Effect of Human Flavin-Containing Monooxygenase 3 Polymorphism on the Metabolism of Aurora Kinase Inhibitors

Effect of Human Flavin-Containing Monooxygenase 3 Polymorphism on the Metabolism of Aurora Kinase Inhibitors

Aurora kinases were recently identified as a potential target in anticancer therapy and, amongst their available inhibitors, Tozasertib (VX-680) and Danusertib (PHA-739358) have been indicated as possible substrates of human flavin-containing monooxygenase 3 (hFMO3). Here we report the in vitro rate...

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Bibliographic Details
Main Authors: Sheila J. Sadeghi, Gianfranco Gilardi, Gianluca Catucci, Andrea Occhipinti, Massimo Maffei
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:International Journal of Molecular Sciences
Subjects:
phase I
drug metabolism
FMO3
polymorphism
enzyme kinetics
VX-680
PHA-739358
LC-MS
Online Access:http://www.mdpi.com/1422-0067/14/2/2707

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http://www.mdpi.com/1422-0067/14/2/2707

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